Metformin Treatment for Four Years to Reduce Total and Visceral Fat in Low Birth Weight Girls with Precocious Pubarche
نویسندگان
چکیده
منابع مشابه
Metformin treatment for four years to reduce total and visceral fat in low birth weight girls with precocious pubarche.
CONTEXT AND OBJECTIVE A low birth weight (LBW) tends to be followed by overweight due to an excess of fat, including visceral fat. LBW girls with precocious pubarche (PP) (pubic hair < 8 yr) are at high risk for developing an adipose state of hyperinsulinemic androgen excess that leads toward early menarche. We explored the effects of insulin sensitization with metformin in LBW-PP girls. SETTIN...
متن کاملEarly metformin therapy to delay menarche and augment height in girls with precocious pubarche.
OBJECTIVE To study the effects of early metformin treatment on menarche, height, and polycystic ovary syndrome (PCOS) markers. Low-birthweight (LBW) girls with precocious pubarche (PP) are at risk for an early menarche (<12 years), an adult stature below target level, and PCOS. Hyperinsulinemic insulin resistance is thought to be a key factor. DESIGN Open-label, randomized study. SETTING Un...
متن کاملA comparative study on growth indicators of children born with low birth weight and normal birth weight in 2 years after birth.
وزن هنگام تولد در تعیین فاکتور امید به زندگی کودک و پیش بینی وضع سلامت او در آینده شاخصی بسیار حساس و سودمند بوده و می تواند مسؤول عوارض و اختلالاتی باشد که بعدها در زندگی کودک به وجود می آید. از آنجا که توجه به رشد کودکان تنها به لحاظ جلوگیری از مرگ و میر آنان دارای اهمیت نمی باشد، بلکه بیشتر از نظر پیشگیری از ابتلا به بیماریهای جسمانی، روانی و اجتماعی در آینده مهم است؛ این پژوهش با هدف مقایسه...
متن کاملBirth weight and body fat distribution in adolescent girls.
OBJECTIVE To examine the association between birth weight and body fat distribution in a group of adolescent girls. DESIGN A total of 216 white girls who were born in Southampton had their heights, weights, waist and hip circumferences, and skinfold thicknesses measured when they were aged between 14 and 16 years. RESULTS The girls who were smallest at birth, but who were fattest at time of...
متن کاملAssociation between birth weight and visceral fat in adults.
BACKGROUND Several studies reported inverse associations between birth weight and central adiposity in adults. However, few studies investigated the contributions of different abdominal fat compartments. OBJECTIVE We examined associations between birth weight and adult visceral and subcutaneous abdominal fat in the population-based Fenland study. DESIGN A total of 1092 adults (437 men and 6...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2008
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2008-0013